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When Na ions are taken up into the tubule cell, water cannot follow in the usual amount. The fall in urine Na+ concentration reduces Na+ reabsorption, in part because the reduced concentration gradient towards the interior of tubule cells means a reduced driving force for Na+ influx. The result of osmotic diuresis is a large volume of dilute urine.
Binding to plasma protein is equivalent to a depot in prolonging the duration of the effect by retarding elimination, whereas the intensity of the effect is reduced. If two substances have affinity for the same binding site on the albumin molecule, they may compete for that site.


Distinctions among protective agents are based upon consistency, physicochemical properties (lipophilic, hydrophilic), and the presence of additives. Dusting Powders are sprinkled onto the intact skin and consist of talc, magnesium stearate, silicon dioxide (silica), or starch. They adhere to the skin, forming a low-friction film that attenuates mechanical irritation.
With the long-acting substances marketed initially, this problem was less obvious in comparison with other dependence- producing drugs because of the delayed appearance of withdrawal symptoms.


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