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Conceivably, Ca2+ ions cause the adhesion of factor to a phospholipid surface, as depicted in C. Phospholipids are contained in platelet factor 3 (PF3), which is released from aggregated platelets, and in tissue thromboplastin (B). The sequential activation of several enzymes allows the aforementioned reactions to “snowball”, culminating in massive production of fibrin (p. 148).
At rest, the pathologically elevated flow resistance is compensated by a corresponding decrease in arteriolar resistance, ensuring adequate myocardial perfusion. During exercise, further dilation of arterioles is impossible. As a result, there is ischemia associated with pain.


Applied topically to skin or mucous membranes, amphotericin B is useful in the treatment of candidal mycosis. Because of the low rate of enteral absorption, oral administration in intestinal candidiasis can be considered a topical treatment. Nystatin is used only for topical therapy. Flucytosine is converted in candida fungi to 5-fluorouracil by the action of a specific cytosine deaminase.
Doxycycline is used to treat bacterial infections, including pneumonia and other respiratory tract infections; Lyme disease; acne; infections of skin, genital, and urinary systems; and anthrax (after inhalational exposure). It is also used to prevent malaria. Doxycycline is in a class of medications called tetracycline antibiotics. It works by preventing the growth and spread of bacteria.


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