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Discontinuance of hormone administration would be followed by menstruation. The physiological time course of estrogen- progesterone release is simulated in the so-called biphasic (sequential) preparations (A). In monophasic preparations, estrogen and progestin are taken concurrently.
Verapamil thus produces negative chrono-, dromo-, and inotropic effects. Indications. Verapamil is used as an antiarrhythmic drug in supraventricular tachyarrhythmias. In atrial flutter or fibrillation, it is effective in reducing ventricular rate by virtue of inhibiting AV-conduction. Verapamil is also employed in the prophylaxis of angina pectoris attacks and the treatment of hypertension.


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The resultant increase in membrane permeability, e. g. , to K+ ions, accounts for the fungicidal effect. Amphotericin B is active against most organisms responsible for systemic mycoses. Because of its poor absorbability, it must be given by infusion, which is, however, poorly tolerated (chills, fever, CNS disturbances, impaired renal function, phlebitis at the infusion site).


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