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Both mechanisms converge via factor X into a common final pathway. The clotting factors are protein molecules. “Activation” mostly means proteolysis (cleavage of protein fragments) and, with the exception of fibrin, conversion into protein-hydrolyzing enzymes (proteases). Some activated factors require the presence of phospholipids (PL) and Ca2+ for their proteolytic activity.
Zestoretic contains a combination of hydrochlorothiazide and lisinopril. Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Lisinopril belongs to a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme. Lisinopril lowers blood pressure and also relieves symptoms of fluid retention.


Therapeutic indications for benzodiazepines include anxiety states associated with neurotic, phobic, and depressive disorders, or myocardial infarction (decrease in cardiac stimulation due to anxiety); insomnia; preanesthetic (preoperative) medication; epileptic seizures; and hypertonia of skeletal musculature (spasticity, rigidity).
Substitution on the amino group reduces affinity for ?-receptors, but increases it for ?-receptors (exception: ?-agonist phenylephrine), with optimal affinity being seen after the introduction of only one isopropyl group. Increasing the bulk of the amino substituent favors affinity for ?2-receptors (e. g. , fenoterol, salbutamol).


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