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Overdosage may induce hypercalcemia with deposits of calcium salts in tissues (particularly in kidney and blood vessels): calcinosis. The polypeptide parathormone is released from the parathyroid glands when plasma Ca2+ level falls. It stimulates osteoclasts to increase bone resorption; in the kidneys, it promotes calcium reabsorption, while phosphate excretion is enhanced.
Both factors can be altered pathologically (e.g., in smokerís cough, bronchitis) or can be adversely affected by drugs (atropine, antihistamines). Pharmaceutical preparations applied to the outer skin are intended either to provide skin care and protection from noxious influences (A), or to serve as a vehicle for drugs that are to be absorbed into the skin.

 

Reabsorption will be nearly complete, because the free concentration of a lipophilic drug in plasma is low (lipophilic substances are usually largely proteinbound). The situation portrayed for a lipophilic non-metabolizable drug would seem undesirable because pharmacotherapeutic measures once initiated would be virtually irreversible (poor control over blood concentration).
Infertility is caused by suppression of spermatogenesis or follicle maturation. Most cytostatics disrupt DNA metabolism. This entails the risk of a potential genomic alteration in healthy cells (mutagenic effect). Conceivably, the latter accounts for the occurrence of leukemias several years after cytostatic therapy (carcinogenic effect).

 

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