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In this manner, they will maintain circulatory filling pressure for many hours. On the other hand, volume substitution is only transiently needed and therefore complete elimination of these colloids from the body is clearly desirable.
Agents for chemical disinfection ideally should cause rapid, complete, and persistent inactivation of all germs, but at the same time exhibit low toxicity (systemic toxicity, tissue irritancy, antigenicity) and be non-deleterious to inanimate materials. These requirements call for chemical properties that may exclude each other; therefore, compromises guided by the intended use have to be made.

 

CN- binds with high affinity to trivalent iron and thereby arrests utilization of oxygen via mitochondrial cytochrome oxidases of the respiratory chain. An internal asphyxiation (histotoxic hypoxia) ensues while erythrocytes remain charged with O2 (venous blood colored bright red).
Merck’s Japanese subsidiary launched Lipola M (simvastatin ODT), a line extension of its block-buster, Zocor®, a cholesterol-lowering drug, in response to seventeen generic registrations of simvastatin applied for in Japan in 200424. Marketers build a better brand and company image when they offer a unique easier-to-take form that satisfies the need of an underserved patient population.

 

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