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Since there is delayed gastric emptying during the attack, drug absorption can be markedly retarded, hence effective plasma levels are not obtained. Because metoclopramide stimulates gastric emptying, it promotes absorption of ingested analgesic drugs and thus facilitates pain relief. If acetylsalicylic acid is administered i. v. as the lysine salt, its bioavailability is complete.
An ODT may have varying degrees of pregastric absorption and thus, the pharmacokinetic profiles will vary. 29 Therefore, the ODT will not be bioequivalent to the conventional oral dosage form. For example, ODT formulations of selegiline, apomorphine, and buspirone have significantly different pharmacokinetic profiles compared with the same dose administered in a conventional dosage form31,32.


Because histamine plays a pivotal role in the activation of parietal cells, H2-antihistamines also diminish responsivity to other stimulants, e. g. , gastrin (in gas-trin-producing pancreatic tumors, Zollinger- Ellison syndrome).
With oral administration of pancreatic enzymes, allowance must be made for their partial inactivation by gastric acid (the lipases, particularly). Therefore, they are administered in acid-resistant dosage forms. Antiflatulents (carminatives) serve to alleviate meteorism (excessive accumulation of gas in the gastrointestinal tract).


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