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The resulting concentration gradient between urine and interstitial fluid is preserved in the case of drugs incapable of permeating the tubular epithelium. However, with lipophilic drugs the concentration gradient will favor reabsorption of the filtered molecules. In this case, reabsorption is not based on an active process but results instead from passive diffusion.
It is given orally to prevent absorption of acutely ingested thallium or to promote clearance from the organism by intercepting thallium that is secreted into the intestines. An anginal pain attack signals a transient hypoxia of the myocardium. As a rule, the oxygen deficit results from inadequate myocardial blood flow due to narrowing of larger coronary arteries.

 

Clozapine may cause dose–dependent seizures and agranulocytosis, necessitating close hematological monitoring. It is strongly sedating. When esterified with a fatty acid, both fluphenazine and haloperidol can be applied intramuscularly as depot preparations.
Stabilization of mast cells. Cromolyn prevents IgE-mediated release of mediators, although only after chronic treatment.

 

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