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The enzyme transpeptidase cross-links the peptide chains of adjacent aminosugar chains. Inhibitors of cell wall synthesis are suitable antibacterial agents, because animal and human cells lack a cell wall. They exert a bactericidal action on growing or multiplying germs.
Besides oxidases, sER also contains reductases and glucuronyl transferases. The latter conjugate glucuronic acid with hydroxyl, carboxyl, amine, and amide groups; hence, also phenolic products of phase I metabolism (Phase II conjugation). Phase I and Phase II metabolites can be transported back into the blood probably via a gradient-dependent carrier or actively secreted into bile.


The central seven-membered ring of the TCAs imposes a 120 angle between the two flanking aromatic rings, in contradistinction to the flat ring system present in phenothiazine type neuroleptics (p. 237). The side chain nitrogen is predominantly protonated at physiological pH.
Infections due to fungi are usually confined to the skin or mucous membranes: local or superficial mycosis. However, in immune deficiency states, internal organs may also be affected: systemic or deep mycosis. Mycoses are most commonly due to dermatophytes, which affect the skin, hair, and nails following external infection.


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