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This procedure, therefore, does not fall under the definition of general anesthesia. According to their mode of application, general anesthetics in the restricted sense are divided into inhalational (gaseous, volatile) and injectable agents. Inhalational anesthetics are administered in and, for the most part, eliminated via respired air. They serve to maintain anesthesia.
In both cases, products are formed that are conjugated to an organic acid residue, e. g. , glucuronic acid, in a subsequent Phase II reaction. Hydroxylation may also take place at nitrogen atoms, resulting in hydroxylamines (e. g. , acetaminophen).


Contrary to timed-release capsules , slow-release tablets have the advantage of being dividable ad libitum; thus, fractions of the dose contained within the entire tablet may be administered. This kind of retarded drug release is employed when a rapid rise in blood level of drug is undesirable.
Special toxic effects include: (reversible) hearing loss, enhanced sensitivity to renotoxic agents.


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