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Dependence on them has all the characteristics of an addiction. Because of rapidly developing tolerance, choral hydrate is suitable only for short-term use. Antihistamines are popular as nonprescription (over-the-counter) sleep remedies (e. g. , diphenhydramine, doxylamine, p. 114), in which case their sedative side effect is used as the principal effect.
Metoclopramide is effective in nausea and vomiting of gastrointestinal origin (5-HT4-receptor agonism) and at high dosage also in chemotherapy- and radiation- induced sickness (low potency antagonism at 5-HT3- and D2-receptors).


The drug effect may, however, become unmasked at daytime when other sedating substances (e. g. , ethanol) are ingested and the patient shows an unusually pronounced response due to a synergistic interaction (impaired ability to concentrate or react).
Patient factors17-20 Orally disintegrating dosage forms are particularly suitable for patients, who for one reason or the other, find it inconvenient to swallow traditional tablets and capsules with an 8-oz glass of water.


How To Get A To Prescript Lipitor

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