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They suppress activation of ?1-receptors without a concomitant enhancement of norepinephrine release. ?1-Blockers may be used in hypertension.
Neuroleptic activity profiles. The marked differences in action spectra of the phenothiazines, their derivatives and analogues, which may partially resemble those of butyrophenones, are important in determining therapeutic uses of neuroleptics.


The initiation of an epileptic attack involves “pacemaker” cells; these differ from other nerve cells in their unstable resting membrane potential, i. e. , a depolarizing membrane current persists after the action potential terminates. Therapeutic interventions aim to stabilize neuronal resting potential and, hence, to lower excitability.
Consequently, the molecular weight of dextran circulating in blood will tend towards a higher mean molecular weight with the passage of time. The most important adverse effect results from the antigenicity of dextrans, which may lead to an anaphylactic reaction. Hydroxyethyl starch (hetastarch) is produced from starch.


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