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Rarely life-threatening, poisoning with atropine is characterized by the following peripheral and central effects: Peripheral: tachycardia; dry mouth; hyperthermia secondary to the inhibition of sweating. Although sweat glands are innervated by sympathetic fibers, these are cholinergic in nature.
From ampules for multiple or single use, the solution is aspirated via a needle into a syringe. The cartridge ampule is fitted into a special injector that enables its contents to be emptied via a needle. An infusion refers to a solution being administered over an extended period of time. Solutions for infusion must meet the same standards as solutions for injection.


Concerning rifabutin see p. 274. Ethambutol. The cause of its specific antitubercular action is unknown. Ethambutol is given orally. It is generally well tolerated, but may cause dosedependent damage to the optic nerve with disturbances of vision (red/green blindness, visual field defects). Pyrazinamide exerts a bactericidal action by an unknown mechanism. It is given orally.
Resultant responses include: relaxation of vascular smooth muscle, as evidenced locally by vasodilation or systemically by hypotension; enhanced capillary permeability with transudation of fluid into tissues— swelling of conjunctiva and mucous membranes of the upper airways, cutaneous wheal formation;


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