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Dopamine agonist-induced nausea in parkinsonian patients can be counteracted with D2-receptor antagonists that penetrate poorly into the CNS (e. g. , domperidone, sulpiride).
Regulations specify, among other things, maximum dosage (permissible single dose, daily maximal dose, maximal amount per single prescription). Prescriptions need to be issued on special forms the completion of which is rigorously monitored.

 

The sartans (candesartan, eprosartan, irbesartan, losartan, and valsartan) are AT1 antagonists that reliably lower high blood pressure. They do not inhibit degradation of kinins and cough is not a frequent side-effect. Bronchodilators. Narrowing of bronchioles raises airway resistance, e.g., in bronchial or bronchitic asthma.
However, in attempting to lower the dose to the minimal effective level, it is necessary to take into account that administration of exogenous glucocorticoids will suppress production of endogenous cortisol due to activation of an inhibitory feedback mechanism.

 

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