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Erythromycin is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including Mycoplasma and legionellosis.
The high therapeutic value of acyclovir is evident in severe infections with H. simplex viruses (e. g. , encephalitis, generalized infection) and varicella-zoster viruses (e. g. , severe herpes zoster). In these cases, it can be given by i. v. infusion. Acyclovir may also be given orally despite its incomplete (15%–30%) enteral absorption. In addition, it has topical uses.


After a few milliseconds, the Na channels close automatically (“inactivation”), the membrane potential returns to resting levels, and the AP is terminated. As long as the membrane potential remains incompletely repolarized, renewed opening of Na channels, hence a new AP, is impossible.
Anti-inflammatory therapy is the more successful the less use is made of asneeded ?2-mimetic medication. Severe cases may, however, require an intensified bronchodilator treatment with systemic ?2-mimetics or theophylline (systemic use only; low therapeutic index; monitoring of plasma levels needed).


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