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By itself, the latter is enzymatically inactive; only after binding to a plasminogen molecule does the complex become effective in converting plasminogen to plasmin. Streptokinase is produced by streptococcal bacteria, which probably accounts for the frequent adverse reactions. Streptokinase antibodies may be present as a result of prior streptococcal infections.
Reduction of germ counts prior to punctures or surgical procedures is desirable if the risk of wound infection is to be minimized. Useful agents include: alcohols (1- and 2-propanol; ethanol 6090%; iodine-releasing agents like polyvinylpyrrolidone [povidone, PVP]-iodine as a depot form of the active principle iodine, instead of iodine tincture), cationic surfactants, and mixtures of these.


Salmeterol is a long-acting inhalative ?2-mimetic (duration: 12 h; onset ~20 min) that offers the advantage of a lower systemic exposure. It is used prophylactically at bedtime for nocturnal asthma.
ACh stimulates receptors located on the subsynaptic membrane of the second neuron. Activation of these receptors causes the nonspecific cation channel to open. The resulting influx of Na+ leads to a membrane depolarization.


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