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Acetaminophen, the amphiphilic acids acetylsalicylic acid (ASA), ibuprofen, and others, as well as some pyrazolone derivatives, such as aminopyrine and dipyrone, are grouped under the label antipyretic analgesics to distinguish them from opioid analgesics, because they share the ability to reduce fever.
Carbamazepine, phenytoin, phenobarbital, and other anticonvulsants (except for gabapentin) induce hepatic enzymes responsible for drug biotransformation. Combinations between anticonvulsants or with other drugs may result in clinically important interactions (plasma level monitoring!).

 

T4-containing thyroglobulin is stored inside the thyroid follicles in the form of thyrocolloid. Upon endocytotic uptake, colloid undergoes lysosomal enzymatic hydrolysis, enabling thyroid hormone to be released as required. A “thyrostatic” effect can result from inhibition of synthesis or release.
Due to their cationic amphiphilic nature, the TCA exert membrane-stabilizing effects that can lead to disturbances of cardiac impulse conduction with arrhythmias as well as decreases in myocardial contractility. All TCA lower the seizure threshold. Weight gain may result from a stimulant effect on appetite.

 

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