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A 2,4-diaminopyrimidine, trimethoprim, has bacteriostatic activity against a broad spectrum of pathogens. It is used mostly as a component of cotrimoxazole. Co-trimoxazole is a combination of trimethoprim and the sulfonamide sulfamethoxazole. Since THF synthesis is inhibited at two successive steps, the antibacterial effect of co-trimoxazole is better than that of the individual components.
Bronchial asthma: Increased sympathetic activity prevents bronchospasm in patients disposed to paroxysmal constriction of the bronchial tree (bronchial asthma, bronchitis in smokers). In this condition, ?2-receptor blockade will precipitate acute respiratory distress (B).

 

The curare ingredient of greatest medicinal importance is d-tubocurarine. This compound contains a quaternary nitrogen atom (N) and, at the opposite end of the molecule, a tertiary N that is protonated at physiological pH. These two positively charged N atoms are common to all other muscle relaxants. The fixed positive charge of the quaternary N accounts for the poor enteral absorbability.
Dependence on them has all the characteristics of an addiction. Because of rapidly developing tolerance, choral hydrate is suitable only for short-term use. Antihistamines are popular as nonprescription (over-the-counter) sleep remedies (e. g. , diphenhydramine, doxylamine, p. 114), in which case their sedative side effect is used as the principal effect.

 

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