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Cutaneous blood flow can range from ~ 0 to 30% of cardiac output, depending on requirements. Heat conduction via the blood from interior sites of production to the body surface provides a controllable mechanism for heat loss. Heat dissipation can also be achieved by increased production of sweat, because evaporation of sweat on the skin surface consumes heat (evaporative heat loss).
Small portions of norepinephrine are inactivated by the enzyme catechol-O-methyltransferase (COMT, present in the cytoplasm of postjunctional cells, to yield normetanephrine), and monoamine oxidase (MAO, present in mitochondria of nerve cells and postjunctional cells, to yield 3,4-dihydroxymandelic acid).


Lynoral (Ethinyl Estradiol) is used for oral contraceptive pill preparations where it is combined with a synthetic progesterone drug. It is a synthetic estrogen similar to the natural female sex hormone estradiol and ia also used as a natural estrogen supplement when the body's production is low, then it is used to control abnormal bleeding from the uterus, and to treat delayed sexual development in females.
Benzodiazepines are the drugs of choice for status epilepticus (see above); however, development of tolerance renders them less suitable for long-term therapy. Clonazepam is used for myoclonic and atonic seizures. Clobazam, a 1,5-benzodiazepine exhibiting an increased anticonvulsant/sedative activity ratio, has a similar range of clinical uses.


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