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Continuous intake of higher doses with maintenance of steady plasma levels leads to loss of efficacy, inasmuch as the organism becomes refractory (tachyphylactic).This “nitrate tolerance” can be avoided if a daily “nitrate-free interval” is maintained, e.g., overnight.
Bupropion (marketed as Wellbutrin, Zyban, Voxra, Budeprion, or Aplenzin; and formerly known as amfebutamone) is an atypical antidepressant and smoking cessation aid.


The anthracycline antibiotics daunorubicin and adriamycin (doxorubicin) may induce cardiomyopathy. Bleomycin can also cause pulmonary fibrosis. The epipodophyllotoxins, etoposide and teniposide, interact with topoisomerase II, which functions to split, transpose, and reseal DNA strands; these agents cause strand breakage by inhibiting resealing. Inhibition of nucleobase synthesis (2).
It is known as a “spindle poison” because it arrests mitosis at metaphase by inhibiting contractile spindle proteins. Its antigout activity is due to inhibition of contractile proteins in the neutrophils, whereby ameboid mobility and phagocytotic activity are prevented.


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