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Due to the reduced supply of fluid, secretion of nasal mucus decreases. In coryza, nasal patency is restored. However, after vasoconstriction subsides, reactive hyperemia causes renewed exudation of plasma fluid into the interstitial space, the nose is “stuffy” again, and the patient feels a need to reapply decongestant. In this way, a vicious cycle threatens.
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The immediate threat results not so much from the loss of erythrocytes, i. e. , oxygen carriers, as from the reduction in volume of circulating blood. To eliminate the threat of shock, replenishment of the circulation is essential. With moderate loss of blood, administration of a plasma volume expander may be sufficient. Blood plasma consists basically of water, electrolytes, and plasma proteins.
Abciximab is a chimeric human-murine monoclonal antibody directed against GPIIb/IIIa that blocks the fibrinogen-binding site and thus prevents attachment of fibrinogen. The peptide derivatives, eptifibatide and tirofiban block GPIIB/IIIA competitively, more selectively and have a shorter effect than does abciximab.

 

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