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Synthesis of clotting factors depends on the intrahepatocytic concentration ratio of coumarins to vitamin K. The dose required for an adequate anticoagulant effect must be determined individually for each patient (one-stage prothrombin time).
Rifampin is frequently given in combination with one or both of the following agents: Dapsone is a sulfone that, like sulfonamides, inhibits dihydrofolate synthesis (p. 272). It is bactericidal against susceptible strains of M. leprae. Dapsone is given orally. The most frequent adverse effect is methemoglobinemia with accelerated erythrocyte degradation (hemolysis).


Neuromuscular transmission (B) of motor nerve impulses to the striated muscle fiber takes place at the motor endplate. The nerve impulse liberates acetylcholine (ACh) from the axon terminal. ACh binds to nicotinic cholinoceptors at the motor endplate.
Effects are delayed and apparently unrelated to the mechanisms responsible for anticonvulsant and cardiovascular actions, respectively. III. Prophylaxis With continued treatment for 6 to 12 months, lithium salts prevent the recurrence of either manic or depressive states, effectively stabilizing mood at a normal level. Schizophrenia is an endogenous psychosis of episodic character.


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