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It should be kept in mind that antibiotics also damage the intestinal flora which, in turn, can give rise to diarrhea. Astringents such as tannic acid (home remedy: black tea) or metal salts precipitate surface proteins and are thought to help seal the mucosal epithelium. Protein denaturation must not include cellular proteins, for this would mean cell death.
Since release is also blocked, the effect develops more rapidly than does that of thioamides. Clinical applications include: preoperative suppression of thyroid secretion according to Plummer with Lugol’s solution (5% iodine + 10% potassium iodide, 50–100 mg iodine/d for a maximum of 10 d).In thyrotoxic crisis, Lugol’s solution is given together with thioamides and ?-blockers.


On the other hand, clinical evidence suggests that ?-blockers produce favorable effects in certain forms of congestive heart failure (idiopathic dilated cardiomyopathy). Bradycardia, A-V block: Elimination of sympathetic drive can lead to a marked fall in cardiac rate as well as to disorders of impulse conduction from the atria to the ventricles.
Thyroid overactivity in Graves’ disease (A) results from formation of IgG antibodies that bind to and activate TSH receptors. Consequently, there is overproduction of hormone with cessation of TSH secretion. Graves’ disease can abate spontaneously after 1–2 y. Therefore, initial therapy consists of reversible suppression of thyroid activity by means of antithyroid drugs.


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