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Mitosis is preceded by replication of chromosomes (DNA synthesis) and increased protein synthesis (RNA synthesis). Existing DNA (gray) serves as a template for the synthesis of new (blue) DNA or RNA. De novo synthesis may be inhibited by: Damage to the template (1). Alkylating cytostatics are reactive compounds that transfer alkyl residues into a covalent bond with DNA.
The uncharged form can penetrate the perineurium and enters the endoneural space, where a fraction of the drug molecules regains a positive charge in keeping with the local pH.
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