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Various scientists41 have developed new in vitro methods that allow an accurate determination of disintegration test. The disintegration test is performed using a texture analyzer instrument. In this test, a flat-ended cylindrical probe penetrates into the disintegrating tablet immersed in water.
The proteins are used as “viral enzymes” catalyzing viral multiplication (e. g. , DNA polymerase and thymidine kinase), as capsomers, or as coat components, or are incorporated into the host cell membrane. (5) Individual components are assembled into new virus particles (maturation). (6) Release of daughter viruses results in spread of virus inside and outside the organism.

 

Thus, the butyrophenones carry an increased risk of adverse motor reactions because they lack anticholinergic activity and, hence, are prone to upset the balance between striatal cholinergic and dopaminergic activity. Derivatives bearing a piperazine moiety (e. g. , trifluperazine, fluphenazine) have greater antipsychotic potency than do drugs containing an aliphatic side chain.
Cyclosporin A is an antibiotic polypeptide from fungi and consists of 11, in part atypical, amino acids. Given orally, it is absorbed, albeit incompletely. In lymphocytes, it is bound by cyclophilin, a cytosolic receptor that inhibits the phosphatase calcineurin. The latter plays a key role in T-cell signal transduction.

 

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