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All dermatologic agents having a lipophilic base adhere to the skin as a water-repellent coating.
Drug dissolution and absorption as well as onset of clinical effect and drug bioavailability may be significantly greater than those observed from conventional dosage forms6-8. Although chewable tablets have been on the market for some time, they are not the same as the new ODTs. Patients for whom chewing is difficult or painful can use these new tablets easily.


In unphysiologically high concentrations, cortisol or other glucocorticoids suppress all phases (exudation, proliferation, scar formation) of the inflammatory reaction, i. e. , the organismís defensive measures against foreign or noxious matter. This effect is mediated by multiple components, all of which involve alterations in gene transcription.
Degradation products of enflurane or isoflurane (fraction biotransformed <2%) are of no concern. Halothane exerts a pronounced hypotensive effect, to which a negative inotropic effect contributes. Enflurane and isoflurane cause less circulatory depression.


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