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Predictable effects that derive from the known pharmacological drug properties. Examples are: masculinization of the female fetus by androgenic hormones; brain hemorrhage due to oral anticoagulants; bradycardia due to ?-blockers. 2. Effects that specifically affect the developing organism and that cannot be predicted on the basis of the known pharmacological activity profile.
Delivery systems disintegrate or dissolve in patientís oral cavity, thus releasing the active ingredients which come in contact with the taste buds; hence, taste-masking of the drugs becomes critical to patient compliance.

 

Even when the swallowed portion of an inhaled drug is absorbed in unchanged form, administration by this route has the advantage that drug concentrations at the bronchi will be higher than in other organs. The efficiency of mucociliary transport depends on the force of kinociliary motion and the viscosity of bronchial mucus.
Cutaneous blood flow can range from ~ 0 to 30% of cardiac output, depending on requirements. Heat conduction via the blood from interior sites of production to the body surface provides a controllable mechanism for heat loss. Heat dissipation can also be achieved by increased production of sweat, because evaporation of sweat on the skin surface consumes heat (evaporative heat loss).

 

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