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Uses. The quaternary carbamate neostigmine is employed as an indirect parasympathomimetic in postoperative atonia of the bowel or bladder. Furthermore, it is needed to overcome the relative ACh-deficiency at the motor endplate in myasthenia gravis or to reverse the neuromuscular blockade caused by nondepolarizing muscle relaxants (decurarization before discontinuation of anesthesia).
Drugs used to counteract drug overdosage are considered under the appropriate headings, e. g. , physostigmine with atropine; naloxone with opioids; flumazenil with benzodiazepines; antibody (Fab fragments) with digitalis; and N-acetyl-cysteine with acetaminophen intoxication. Chelating agents (A) serve as antidotes in poisoning with heavy metals.


At the same time, it has a mineralocorticoid-like action (due to inhibition of 11-?-hydroxysteroid dehydrogenase) that promotes renal reabsorption of NaCl and water. It may, therefore, exacerbate hypertension, congestive heart failure, or edemas. It is obsolete. III. Eradication of Helicobacter pylori C.
O2 demand falls because of the ensuing decrease in the two variables that determine systolic wall tension (afterload): ventricular filling volume and aortic blood pressure. Calcium antagonists (B) decrease O2 demand by lowering aortic pressure, one of the components contributing to afterload.


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