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Trazodone is an antidepressant medication. It is thought to increase the activity of one of the brain chemicals (serotonin) which may become unbalanced and cause depression. Trazodone is used to treat depression. It may also be used for relief of anxiety disorders (eg, sleeplessness, tension) and chronic pain. Trazodone may also be used for other purposes not listed in this medication guide.
Metabolically active vitamin D hormone results from two successive hydroxylations: in the liver at position 25 ( calcifediol) and in the kidney at position 1 ( calcitriol = vit. D hormone). 1-Hydroxylation depends on the level of calcium homeostasis and is stimulated by parathormone and a fall in plasma levels of Ca2+ or phosphate.


Sympathetic Transmitter Substances Whereas acetylcholine (see p. 98) serves as the chemical transmitter at ganglionic synapses between first and second neurons, norepinephrine (= noradrenaline) is the mediator at synapses of the second neuron (B).
Clearance rates of these substances can be used to determine renal or hepatic blood flow. As the chief organ of drug biotransformation, the liver is richly supplied with blood, of which 1100 mL is received each minute from the intestines through the portal vein and 350 mL through the hepatic artery, comprising nearly 1/3 of cardiac output.


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