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Bisphosphonates structurally mimic endogenous pyrophosphate, which inhibits precipitation and dissolution of bone minerals. They retard bone resorption by osteoclasts and, in part, also decrease bone mineralization. Indications include: tumor osteolysis, hypercalcemia, and Pagetís disease.
I. Drugs for selective control of sinoatrial and AV nodes. In some forms of arrhythmia, certain drugs can be used that are capable of selectively facilitating and inhibiting (green and red arrows, respectively) the pacemaker function of sinoatrial or atrioventricular cells. Sinus bradycardia. An abnormally low sinoatrial impulse rate (<60/min) can be raised by parasympatholytics.


Conversely, most of the psychotomimetic effects are annulled by neuroleptics having 5-HT2A antagonist activity (e. g. clozapine, risperidone).
Suitable particles can be obtained by precipitation of apolar, poorly water-soluble complexes consisting of anionic insulin and cationic partners, e. g. , the polycationic protein protamine or the compound aminoquinuride (Surfen). In the presence of zinc and acetate ions, insulin crystallizes; crystal size determines the rate of dissolution.


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