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This technology provides for pharmacokinetic benefits of orally administered nanoparticles (less than 2 microns) in the form of a rapidly disintegrating tablet matrix and wide range of doses (up to 200mg of API per unit). NanoCrystal colloidal dispersions of drug substance are combined with water-soluble GRAS (generally regarded as safe) ingredients, filled into blisters, and lyophilized.
However, if a high dose (100) is applied, there is an extended period of time during which the plasma level will remain in a concentration range (between 90 and 20) in which a change in concentration does not cause a change in the size of the effect. Thus, at high doses (100), the time-effect curve exhibits a kind of plateau.

 

Naturally susceptible bacterial strains can be transformed under the influence of antibacterial drugs into resistant ones (acquired resistance), when a random genetic alteration (mutation) gives rise to a resistant bacterium. Under the influence of the drug, the susceptible bacteria die off, whereas the mutant multiplies unimpeded.
Early administration of progestin reinforces the inhibition of CNS regulatory mechanisms, prevents both normal endometrial growth and conditions for ovum implantation, and decreases penetrability of cervical mucus for sperm cells.The two latter effects also act to prevent conception.

 

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